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Special Issues in Autoimmunity Reviews and Journal of Autoimmunity 
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Common variable immunodeficiency (CVID) (also known as Acquired hypogammaglobulinemia) is a group of approximately 150 primary immunodeficiencies (PIDs), whi...
Alfredo Corell's insight:
Documentary for all people. Short and easy to understand
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Rheumatoid arthritis is the most commonly diagnosed systemic inflammatory arthritis. Women, smokers, and those with a family history of the disease are most often affected.
Alfredo Corell's insight:
One year old, but still, an interesting page (very clear and understandable Tables)
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Immunodeficiency and Frequent or Recurrent Infections http://t.co/5ZnsCKGr... Immunodeficiency and Frequent or Recurrent Infections Editor: V. Dimov, M.D., Allergist/Immunologist and Assistant Professor at University of Chicago
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Neutrophils are essential components of the haematopoietic and immune system, and quantitative or qualitative abnormalities of neutrophils can result in life-threatening infection. Neutropenia is a low neutrophil count and results from decreased production, accelerated utilisation, increased destruction, or a shift in compartments. A combination of these mechanisms may be present. Causes can be congenital or acquired. The most serious complication of neutropenia is infection, which can be fatal. The source is usually endogenous flora of the gut and mucosa (commonly Staphylococcus and gram-negative organisms). Fungal infections occur with increased frequency, but there is no increased risk of viral or parasitic infection. Common sites of infection include mucous membranes (gingivitis, stomatitis, perirectal abscesses), skin (cellulitis), and lungs (pneumonia).
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#Immunology: New Diagnostic Criteria for Common Variable Immunodeficiency (#CVID): IV or SubQ #Immunoglobulin? http://t.co/hQSMeiFj8y … #PI
Alfredo Corell's insight:
Summary
Common variable immune deficiency (CVID) is the most frequent symptomatic primary immune deficiency in adults. The standard of care is intravenous immunoglobulin (IVIG) or subcutaneous immunoglobulin (scIG) therapy. The cause of CVID is currently unknown, and there is no universally accepted definition of CVID. This creates problems in determining which patients will benefit from IVIG/scIG treatment. In this paper, we review the difficulties with the commonly used European Society of Immune Deficiencies (ESID) and the Pan American Group for Immune Deficiency (PAGID) definition of CVID. We propose new criteria for the diagnosis of CVID, which are based on recent scientific discoveries. Improved diagnostic precision will assist with treatment decisions including IVIG/scIG replacement. We suggest that asymptomatic patients with mild hypogammaglobulinaemia are termed hypogammaglobulinaemia of uncertain significance (HGUS). These patients require long-term follow-up, as some will evolve into CVID.
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Nueva edición de la obra de referencia en Medicina Interna en español, dirigida por el profesor Rozman y co-dirigida por el profesor Cardellach, cuenta con la colaboración de 400 expertos en cada área, que pertenecen a las principales facultades y hospitales de España, Latinoamérica y otros países.
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Alfredo Corell's insight:
You can find very good material at his page:
A simple review of the Immune Systems (for kids and families): http://www.info4pi.org/aboutPI/index.cfm?section=aboutPI&content=nurseposter&CFID=1110688&CFTOKEN=51588866
The 10 warning sings of these diseases http://www.info4pi.org/aboutPI/index.cfm?section=aboutPI&content=warningsigns
The key to find expert: http://www.info4pi.org/expertlocator/index.cfm?section=expertlocator
The 4 stages of immunology testing: http://www.info4pi.org/aboutPI/index.cfm?section=aboutPI&content=algorithm
and a huge amount of links and publications for Patients as well as Professionals.
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Alberto Martini, Dipartimento di Pediatria, Università di Genova, Pediatria II e Reumatologia, Istituto G Gaslini, Genova, Italy http://dx.doi.org/10.1016/j.autrev.2012.07.022,
Systemic juvenile idiopathic arthritis (sJIA) sets well apart from all the other forms of JIA. Several observations show that sJIA is etiopathogenically different from all the other forms of JIA and has a prominent autoinflammatory component. A major role in the pathogenesis is played by two proinflammatory cytokines, interleukin-6 and interleukin-1. The specific inhibition of these two cytokines is going to change not only the therapeutic approach to the disease but also, presumably, its long term prognosis.
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Special Issues in Autoimmunity Reviews and Journal of Autoimmunity
Autoimmunity Reviews and the Journal of Autoimmunity both feature a special issue on diagnostic criteria in autoimmune diseases, to coincide with the 9th International Congress on Autoimmunity in Nice, France, in March 2014.
Here you can read both issues – free access until June 2014.
Diagnostic Criteria in Autoimmune Diseases
Autoimmunity Reviews, Volume 13, Issues 4–5, Pages 331-594 (April–May 2014)
Edited by Yehuda Shoenfeld and M. Eric Gershwin
Diagnostic Criteria in Autoimmune Diseases
Journal of Autoimmunity, Volumes 48–49, Pages 1-152 (February–March 2014)
Edited by M. Eric Gershwin and Yehuda Shoenfeld