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New study that identifies a possible causative link between gut microbiota and sex hormone production that may drive protection from autoimmunity.
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Scooped by Alfredo Corell |
Scoop.it!
BrainImmune's comment,
December 13, 2013 10:41 AM
thank you for noticing that
Alfredo Corell's comment,
December 13, 2013 12:44 PM
it's an impressive connection!!
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Program in Genetics and Genome Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
AbstractMicrobial exposures and sex hormones exert potent effects on autoimmune diseases, many of which are more prevalent in women. We demonstrate that early-life microbial exposures determine sex hormone levels and modify progression to autoimmunity in the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D). Colonization by commensal microbes elevated serum testosterone and protected NOD males from T1D. Transfer of gut microbiota from adult males to immature females altered the recipient's microbiota, resulting in elevated testosterone and metabolomic changes, reduced islet inflammation and autoantibody production, and robust T1D protection. These effects were dependent on androgen receptor activity. Thus, the commensal microbial community alters sex hormone levels and regulates autoimmune disease fate in individuals with high genetic risk.