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A study showing that vasoactive intestinal peptide (VIP) is able to reduce the pathogenic profile of Th17 cells and favoring Treg cell differentiation. 
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CONCLUSIONS:
This study highlights the value of characterizing temporally resolved microbiota dynamics for a better understanding of FMT efficacy and provides potentially useful diagnostic indicators for monitoring FMT success in the treatment of ulcerative colitis.
Alfredo Corell's insight:
Am J Gastroenterol 2013; 108:1620–1630; doi:10.1038/ajg.2013.257; published online 24 September 2013 Temporal Bacterial Community Dynamics Vary Among Ulcerative Colitis Patients After Fecal Microbiota TransplantationSieglinde Angelberger MD1, Walter Reinisch MD1, Athanasios Makristathis PhD2, Cornelia Lichtenberger1, Clemens Dejaco MD1, Pavol Papay MD1, Gottfried Novacek MD1, Michael Trauner MD1, Alexander Loy PhD3 and David Berry PhD3
Divulgative resumen: http://medicalxpress.com/news/2013-09-microbial-inflamed-gut.html
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Antibodies play a significant role in countering foreign threats and ensuring specificity of self/non-self recognition.
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/PRNewswire/ -- A link between gluten and the immune system has literally been visualized in new research published today in a leading scientific journal, Immunity.
The new at "The Sacramento Bee" http://www.sacbee.com/2012/10/11/4902859/link-between-gluten-and-immune.html
The article at "Immunity" (Cell Press) http://www.sciencedirect.com/science/article/pii/S1074761312004190
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Trends in Immunology, 11 December 2013
AuthorsYusuke Endo,Kiyoshi Hirahara,Ryoji Yagi,Damon J. Tumes,Toshinori Nakayama
Alfredo Corell's insight:
Immunological memory is a hallmark of adaptive immunity. Memory CD4 T helper (Th) cells are central to acquired immunity, and vaccines for infectious diseases are developed based on this concept. However, memory Th cells also play a critical role in the pathogenesis of various chronic inflammatory diseases, including asthma. We refer to these populations as ‘pathogenic memory Th cells.’ Here, we review recent developments highlighting the functions and characteristics of several pathogenic memory type Th2 cell subsets in allergic inflammation. Also discussed are the similarities and differences between pathogenic memory Th2 cells and recently identified type 2 innate lymphoid cells (ILC2), focusing on cytokine production and phenotypic profiles.
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Alfredo Corell's insight:
Overview: The researchers found that the group taking HydroEye had a significant improvement in irritation symptoms, a smoother corneal surface, and lower levels of inflammatory biomarkers compared to those in the placebo group. Methods In this multi-center, randomized, controlled trial, 38 postmenopausal women with Dry Eye Syndrome (moderate to severe KCS) received 4 softgels daily of HydroEye® or placebo, and were evaluated at 0, 4, 12, 24 weeks for a number of efficacy outcomes. Conjunctival impression cytologies were obtained (pressing a membrane to the conjunctiva to collect cell samples) and stained for inflammatory biomarkers HLA-DR & CD11c. Link to Cornea Journal: http://journals.lww.com/corneajrnl/Abstract/publishahead/Long_term_Supplementation_With_n_6_and_n_3_PUFAs.98510.aspx Link to product web: http://www.sciencebasedhealth.com/HydroEye-Powerful-Dry-Eye-Relief-P43.aspx
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The NPC became part of NICE in April 2011.
During this transition period some change has been necessary to best align the work of the NPC with the NICE portfolio. This has included, revising the production processes for the development of future outputs so that they are easily identifiable as NICE products and also continue to be recognised and valued by our existing audience.
From 15th May 2012, the team delivering the work of the NPC will form the NICE Medicines and Prescribing Centre and will sit alongside the Clinical Guidelines team within the Centre for Clinical Practice. The primary objective of the Medicines and Prescribing Centre will continue to be the provision of support for those using medicines across the NHS, including information on medicines, prescribing advice, training and education, governance and decision-making. All future Medicines and prescribing outputs will be published on the NICE website and signposted from the Medicines and prescribing homepage.
Although no new Medicines and prescribing content will be published to the NPC legacy website, the extensive catalogue of existing publications, resources and e-learning materials will still be available to view and download for as long as the information contained within them remains accurate and up-to-date. Feedback and enquiries can be sent to nice@nice.org.uk
New NICE web page:
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El ejercicio regular reduce el riesgo de enfermedades metabólicas y cardiorespiratorias crónicas. El ejercicio regular tiene efectos ANTI-INFLAMATORIOS
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These results indicate that VIP may have promising effects in the early phase of RA targeting the inhibition of pathogenic Th17 cells,and favoring Treg cell differentiation.
Source: Journal of Leukocyte Biology, 2015. DOI: 10.1189/jlb.3A0714-327R
Read more: Journal of Leukocyte Biology
See also: IL-17: A Promising Therapeutic Target in Several Chronic Inflammatory Diseases
Important New Features and Glucocorticoid-Resistance of Pro-Inflammatory Th17 Cells